In the CANFOUR part examining PDAC, 9 patients in the first cohort of 31 are currently on treatment with CAN04 in combination with gemcitabine and nab-paclitaxel. An interim analysis of 20 patients in October 2020 showed a 40% response rate (including 2 patients that had not been treated long enough for a second confirmatory CT-scan), which is higher than 23% reported as historical control 1 .

CAN04 is a humanized and antibody-dependent cellular cytotoxicity (ADCC)-enhanced IgG1 antibody targeting IL1RAP with two modes of action: blocking IL-1 alpha and beta signaling and triggering ADCC. This study included 22 patients with non–small cell lung cancer (NSCLC; four patients), pancreatic ductal adenocarcinoma (six patients), or

Commissioned Research: CANFOUR progressing according to plan. In addition, early signs of efficacy during treatment with CAN04 will be investigated.. Clinical Trials Registry. ICH GCP. Acronym, CANFOUR.

Canfour can04

Thereby, CAN04 can counteract the contribution of the IL-1 system to the immune suppressive tumor microenvironment and development of resistance to chemotherapy. CAN04 is investigated in two clinical trials. CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung The results showed that CAN04 has a very high level of safety and positive effects on biomarkers that can be linked to cancer was observed. Good safety profile up to 10 mg/kg. A decrease in the biomarkers IL-6 and CRP. Stable disease in 43 per cent of patients. The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer.

These new Phase IIa data, combined with initial interim data reported in December 2019, continue to support the hypothesis that CAN04 has a synergistic benefit with chemotherapy, in our view.

2019-08-26

Thereby, CAN04 can counteract the contribution of the IL-1 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining two different first line chemotherapy combinations in patients with non-small cell lung cancer or pancreatic cancer, as well as monotherapy in late stage patients. CAN04 is presently investigated in combination with pembrolizumab (a common immunotherapy) to study the combination of these two immunotherapies. The results in this trial together with those The phase IIa part is also expected to start in Q4 2018, investigating efficacy of CAN04 as both monotherapy as well as combination therapy in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer. Results during Q4 2018 The first patient in the study started therapy in September 2017.

(R) Cantargia rapporterar att första patienten behandlats med CAN04 i en fas I antikroppen CAN04, studeras i den kliniska fas I/IIa-studien CANFOUR med

CAN04 increased the anti-tumor effects in mice when combined with different registered platinum-based therapies (cisplatin, carboplatin or oxaliplatin) in either a patient-derived NSCLC model or CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The study is focused on CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining first line chemotherapy combination with two different standard regimes in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC), as well as monotherapy in late stage patients (www.clinicaltrials.gov). The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1a and IL-1ß signaling. Thereby, CAN04 can counteract the contribution of the IL-1 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining two different first line chemotherapy combinations in patients with non-small cell lung cancer or pancreatic cancer, as well as monotherapy in late stage patients. CAN04 is presently investigated in combination with pembrolizumab (a common immunotherapy) to study the combination of these two immunotherapies. The results in this trial together with those The phase IIa part is also expected to start in Q4 2018, investigating efficacy of CAN04 as both monotherapy as well as combination therapy in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer. Results during Q4 2018 The first patient in the study started therapy in September 2017.

6. mar 2020 CANFOUR - En doseopptrappingsstudie for å evaluere sikkerheten og toleransen av flere doser med CAN04-antistoff hos pasienter med solide See Tweets about #canfour on Twitter. #Cantargia Reports Interim #Data from Phase 2A #CANFOUR Trial of CAN04 in #Pancreatic and #LungCancers Cantargia reports treatment of first patient with antibody CAN04 in the phase IIa part of CANFOUR trial. COMS has become a wholly-owned subsidiary of 10 mar 2021 Edison menar att Can04 är ”tydligt differentierad” från Novartis kandidat 2021 och uppdaterade resultat från Cantargias fas 2a-studie Canfour It focuses on the development of CAN04 for the treatment of non-small cell Cantargia reports first patient treated in CANFOUR pancreatic cancer phase IIa 20 Aug 2020 The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung 10 feb 2021 Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker Redeye bedömer att uppdaterade data från CANFOUR-studien ytterligare stärker utsikterna för antikroppsbehandlingen CAN04 och kan tala för en Cantargia.
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En interimsanalys av 20 patienter i oktober 2020 visade på s.k. respons i 40% av patienterna (inkluderande 2 patienter som inte behandlats tillräckligt länge för en andra, bekräftande CT-scan), vilket är högre än historiska Cantargia AB: Cantargia reports first patient treated with CAN04 in a US phase I study investigating combination with pembrolizumab. Publicerad: 2020-10-02 (Cision) Cantargia AB: Cantargia rapporterar att första patienten behandlats med CAN04 i en fas I studie i USA som studerar kombination med pembrolizumab CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung Vi tror att ändå att besked breddat kliniskt program för CAN04, nya CANFOUR-data och ett ökade fokus på CAN10 skapar förutsättningar för fortsatt positiv utveckling för aktien. Det motiverade värdet höjs till 72 kronor från tidigare 39 kronor. Utgångspunkten är proteinet IL1RAP som är involverat i ett flertal sjukdomar och där Cantargia etablerat en plattform.

CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 studeras i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker Cantargia's Phase IIa CANFOUR trial investigates CAN04 in a combination with a different chemotherapy (platinum-based as opposed to Redeye bedömer att uppdaterade data från CANFOUR-studien ytterligare stärker utsikterna för antikroppsbehandlingen CAN04 och kan tala CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining two different first line chemotherapy combinations in Vi tror att den trend som CAN04 visade upp i de preliminära data som Även om CANFOUR-studien, som pågått sedan 2017, har dragits med patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and First part of CANFOUR is nearing completion – Updated 16 May 2018 Cantargia's lead candidate is the antibody CAN04, which has a dual mechanism of Syftet är en utökad satsning på Cantargias huvudprojekt CAN04 lovande subgruppen patienter i den pågående kliniska studien CANFOUR. Cantargia utvecklar antikroppen CAN04 för cancerbehandling.
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10. maaliskuu 2021 Cantargia's Phase IIa CANFOUR trial investigates CAN04 in a combination with a different chemotherapy (platinum-based as opposed to

Preliminära interimsdata som bolaget presenterade i december i 2019-08-26 2019-01-25 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining first line chemotherapy combination with two different standard regimes in 31 patients with NSCLC (gemcitabine Utgångspunkten är proteinet IL1RAP som är involverat i ett flertal sjukdomar och där Cantargia etablerat en plattform.

In addition, early signs of efficacy during treatment with CAN04 will be investigated.. Clinical Trials Registry. ICH GCP. Acronym, CANFOUR. Study Design Info.

Sedan början av 2019 driver Cantargia en fas 2a-studie, (CANFOUR) på patienter med metastaserad lung- och bukspottkörtelcancer utan tidigare behandling med cellgifter. Preliminära interimsdata som bolaget presenterade i december i 2019-08-26 2019-01-25 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining first line chemotherapy combination with two different standard regimes in 31 patients with NSCLC (gemcitabine Utgångspunkten är proteinet IL1RAP som är involverat i ett flertal sjukdomar och där Cantargia etablerat en plattform.

Utgångspunkten är proteinet IL1RAP som är involverat i ett flertal sjukdomar och där Cantargia etablerat en plattform. Huvudprojektet, antikroppen CAN04, studeras i den kliniska fas I/IIa-studien CANFOUR med primärt fokus mot icke-småcellig lungcancer och bukspottskörtelcancer. Studien genomförs som både monoterapi och kombinationsterapi. The company announces the status of the ongoing phase I/IIa clinical trial CANFOUR investigating the lead compound CAN04 (nidanilimab) and further information on the phase IIa part of the trial.